Macrophages and metabolism in the tumor microenvironment
Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …
population of the tumor microenvironment (TME) that can account for up to 50% of some …
Myeloid-derived suppressor cells as a therapeutic target for cancer
The emergence of immunotherapy has been an astounding breakthrough in cancer
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …
A bispecific CAR-T cell therapy targeting BCMA and CD38 in relapsed or refractory multiple myeloma
H Mei, C Li, H Jiang, X Zhao, Z Huang, D Jin… - Journal of Hematology & …, 2021 - Springer
Background BCMA-specific chimeric antigen receptor-T cells (CAR-Ts) have exhibited
remarkable efficacy in refractory or relapsed multiple myeloma (RRMM); however, primary …
remarkable efficacy in refractory or relapsed multiple myeloma (RRMM); however, primary …
An immune atlas of clear cell renal cell carcinoma
Immune cells in the tumor microenvironment modulate cancer progression and are attractive
therapeutic targets. Macrophages and T cells are key components of the microenvironment …
therapeutic targets. Macrophages and T cells are key components of the microenvironment …
CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade
L Chen, L Diao, Y Yang, X Yi, BL Rodriguez, Y Li… - Cancer discovery, 2018 - AACR
Although treatment with immune checkpoint inhibitors provides promising benefit for patients
with cancer, optimal use is encumbered by high resistance rates and requires a thorough …
with cancer, optimal use is encumbered by high resistance rates and requires a thorough …
Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma
Daratumumab targets CD38-expressing myeloma cells through a variety of immune-
mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell …
mediated mechanisms (complement-dependent cytotoxicity, antibody-dependent cell …
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
S Nath, GR Devi - Pharmacology & therapeutics, 2016 - Elsevier
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages
Tumor‐associated macrophages (TAM s) promote tumor growth and metastasis by
suppressing tumor immune surveillance. Herein, we provide evidence that the …
suppressing tumor immune surveillance. Herein, we provide evidence that the …
Tumor immune microenvironment and immune checkpoint inhibitors in esophageal squamous cell carcinoma
Y Baba, D Nomoto, K Okadome, T Ishimoto… - Cancer …, 2020 - Wiley Online Library
Esophageal squamous cell carcinoma (ESCC) is the main prevalent histological type of
esophageal cancer, predominantly constituting 90% of cases worldwide. Despite the …
esophageal cancer, predominantly constituting 90% of cases worldwide. Despite the …
IL-6 mediates cross-talk between tumor cells and activated fibroblasts in the tumor microenvironment
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple
cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective …
cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective …