Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Cancers develop within complex tissue environments consisting of diverse innate and
adaptive immune cells, along with stromal cells, vascular networks, and many other cellular …

Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …