Tumor-associated macrophages (TAM) promote triple-negative breast cancer (TNBC)
progression. Here, we report BRCA1-IRIS–overexpressing (IRISOE) TNBC cells secrete …

Background: Obesity is a strong predictor of poor prognosis in breast cancer, especially in
postmenopausal women. In particular, tumors in obese patients tend to seed more distant …

Cancer immunotherapy has been heralded as a breakthrough cancer treatment
demonstrating tremendous success in improving tumor responses and survival of patients …

Simple Summary A major challenge in treating cancer is when the cancer spreads from its
original site to other parts of the body, a process also known as metastasis. In order to …

Utilizing targeted therapies capable of reducing cancer metastasis, targeting chemoresistant
and self-renewing cancer stem cells, and augmenting the efficacy of systemic …

Nutrients are essential for cell function. Immune cells operating in the complex tumor
microenvironment (TME), which has a unique nutrient composition, face challenges of …

Multiple factors act in concert to define the fate of disseminated tumor cells (DTC) to enter
dormancy or develop overt metastases. Here, we review these factors in the context of three …

Context Neoplastic cells are characterized by metabolic alterations that sustain tumor
growth. Interventions aimed at modifying metabolic rewiring of cancer cells are currently …

Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …

Average age and obesity prevalence are increasing globally. Both aging and obesity are
characterized by profound systemic metabolic and immunologic changes and are cancer …