Transition metal catalysis has contributed immensely to C–C bond formation reactions over
the last few decades, and alkylation is no exception. The superiority of such methodologies …

Conspectus Conversion of common reactants to diverse products is a key objective of
organic syntheses. Recent developments in transition-metal-catalyzed C–H functionalization …

Machine-learning methods have great potential to accelerate the identification of reaction
conditions for chemical transformations. A tool that gives substrate-adaptive conditions for …

The atropselective iodination of 2-amino-6-arylpyridines catalyzed by chiral disulfonimides
(DSIs) is described. Key to the development of this transformation was the use of a …

This manuscript describes a mild, functional group tolerant, and metal-free C–H
carboxylation that enables direct access to azole-2-carboxylic acids, followed by amide …

We report a versatile method for C2 functionalization of (benz) oxazoles and (benzo)
thiazoles employing a tert-butylimino-tri (pyrrolidino) phosphorane/sodium trifluoroacetate …

Transition-metal-free direct arylation of CH or NH bonds is one of the key emerging
methodologies that is currently attracting tremendous attention. Diaryliodonium salts serve …

Herein we report a method for affording 2-benzyl benzoxazoles from substituted styrenes
and 2-nitrophenols. The success of this method relies on the use of simple reagents, namely …

An efficient method for the C (2)− H arylation of (benz) imidazoles and (benz) oxazoles with
aryl chlorides and aryl bromides under Ni/NHC catalysis has been developed. The main …

We disclose a new general strategy for the site-selective difluoroalkylation of
nonprefunctionalized heteroarenes, such as quinoxaline at the C-8 position, and …