Therapeutic targeting of tumour myeloid cells
ST Barry, DI Gabrilovich, OJ Sansom… - Nature Reviews …, 2023 - nature.com
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
J Kim, HS Kim, JH Chung - Experimental & Molecular Medicine, 2023 - nature.com
In addition to constituting the genetic material of an organism, DNA is a tracer for the
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …
STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in …
ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in …
Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
Therapeutic messenger RNA vaccines enable delivery of whole antigens, which can be
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …
Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising
class of immunotherapeutics that activate innate immunity to increase tumour …
class of immunotherapeutics that activate innate immunity to increase tumour …
The STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
cGAS-STING pathway in cancer biotherapy
Y Wang, J Luo, A Alu, X Han, Y Wei, X Wei - Molecular cancer, 2020 - Springer
The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor
immunity by generating type I interferons. In recent decades, we have witnessed that …
immunity by generating type I interferons. In recent decades, we have witnessed that …
Challenges and opportunities in the clinical development of STING agonists for cancer immunotherapy
L Motedayen Aval, JE Pease, R Sharma… - Journal of clinical …, 2020 - mdpi.com
Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have
been effective in only a small subset of patients and a principal mechanism underlying …
been effective in only a small subset of patients and a principal mechanism underlying …
Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
J Zheng, J Mo, T Zhu, W Zhuo, Y Yi, S Hu, J Yin… - Molecular cancer, 2020 - Springer
Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …