Sarcopenia refers to the gradual loss of skeletal muscle mass and function along with aging
and is a social burden due to growing healthcare cost associated with a super-aging society …

Histone deacetylases (HDACs) are enzymes that regulate the deacetylation of numerous
histone and non-histone proteins, thereby affecting a wide range of cellular processes …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

Denervation induces skeletal muscle atrophy, accompanied by complex biochemical and
physiological changes, with potentially devastating outcomes even an increased mortality …

HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to
denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially …

Examining neural etiologic factors' role in the decline of neuromuscular function with aging
is essential to our understanding of the mechanisms underlying sarcopenia, the age …

Abstract Background Cancer Anorexia Cachexia Syndrome (CACS) is a distinct atrophy
disease negatively influencing multiple aspects of clinical care and patient quality of life …

Controlling access to genomic information and maintaining its stability are key aspects of
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …

Dysregulation of epigenetic mechanisms is emerging as a central event in
neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models …

Loss of innervation of skeletal muscle is a determinant event in several muscle diseases.
Although several effectors have been identified, the pathways controlling the integrated …