Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering
technology that endows the somatic cell genome with totipotency. Since the first report on …

Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell
research and regenerative medicine for the past 20 years. The main biological goal of SCNT …

Abstract The National Institutes of Health (NIH) miniature pig was developed specifically for
xenotransplantation and has been extensively used as a large-animal model in many other …

Faulty epigenetic reprogramming of somatic nuclei is likely to be a major cause of low
success observed in all mammals produced through somatic cell nuclear transfer (SCNT). It …

In 1996, when Dolly the sheep was born, a new, utopian era was expected to begin. Science
fiction and popular culture instantly threatened the public with shortly upcoming human …

Stem cells are characterized by their capability to self‐renew and terminally differentiate into
multiple cell types. Somatic or adult stem cells have a finite self‐renewal capacity and are …

Fertile offspring from somatic cell nuclear transfer (SCNT) is the goal of most cloning
laboratories. For this process to be successful, a number of events must occur correctly. First …

Accumulating evidence suggests that histone hypoacetylation which is partly mediated by
histone deacetylase (HDAC), plays a causative role in the etiology of various clinical …

The effectiveness of somatic cell nuclear transfer (SCNT) in mammals seems to be still
characterized by the disappointingly low rates of cloned embryos, fetuses, and progeny …

Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through
somatic cell nuclear transfer (SCNT), which is known as cloning. Although many mammalian …