As the essential regulators of organ fibrosis, macrophages undergo marked phenotypic and
functional changes after organ injury. These changes in macrophage phenotype and …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Harmonizing cell types across the single-cell community and assembling them into a
common framework is central to building a standardized Human Cell Atlas. Here, we present …

In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can
end up in respiratory failure. Even though the main fibrotic disease affecting the lung is …

To date, pulmonary fibrosis remains an unmet medical need. In this study, we evaluated the
potency of mesenchymal stromal cell (MSC) secretome components to prevent pulmonary …

Pulmonary fibrosis results from a plethora of abnormal pathogenetic events. In idiopathic
pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in …

Rationale: Changes in peripheral blood cell populations have been observed, but not
detailed, at single-cell resolution in idiopathic pulmonary fibrosis (IPF). Objectives: We …

Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a severe
manifestation of CTD that leads to significant morbidity and mortality. Clinically, ILD can …

Aging is a major risk factor associated with increased morbidity and mortality rates observed
during respiratory infections. In this study, we investigated the role of influenza virus …

Metabolic changes are coupled with alteration in protein glycosylation. In this review, we will
focus on macrophages that are pivotal in the pathogenesis of pulmonary fibrosis and …