Chromosomal DNA double-strand breaks (DSBs) are the effective lesion of radiotherapy
and other clastogenic cancer therapeutics, and are also the initiating event of many …

Cellular and biochemical studies of nonhomologous DNA end joining (NHEJ) have long
established that nuclease and polymerase action are necessary for the repair of a very large …

DNA double-stranded breaks (DSBs) are a particularly challenging form of DNA damage to
repair because the damaged DNA must not only undergo the chemical reactions …

The synapsis of DNA ends is a critical step for the repair of double-strand breaks by non-
homologous end joining (NHEJ). This is performed by a multicomponent protein complex …

DNA double strand breaks (DSBs) are common lesions whose misrepair are drivers of
oncogenic transformations. The non-homologous end joining (NHEJ) pathway repairs the …

Errors in mitosis can generate micronuclei that entrap mis-segregated chromosomes, which
are susceptible to catastrophic fragmentation through a process termed chromothripsis. The …

The proteins and protein assemblies involved in DNA repair have been the focus of a
multitude of structural studies for the past few decades. Historically, the structures of these …

DNA double-strand breaks (DSBs) represent one of the most severe threats to genomic
integrity, demanding intricate repair mechanisms within eukaryotic cells. A diverse array of …

Background Recent studies have shown that, owning to its cohesive cleavage, Cas9-
mediated CRISPR gene editing outcomes at junctions of chromosomal rearrangements or …

Repair of DNA double strand breaks by the non-homologous end-joining pathway is
initiated by the binding of Ku to DNA ends. Given its high affinity for ends, multiple Ku …