Immune responses occur in the midst of a variety of cellular stresses that can severely
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …

Protein folding in the endoplasmic reticulum (ER) is an essential cell function. To safeguard
this process in the face of environmental threats and internal stressors, cells mount an …

Understanding how HLA-B27 contributes to the pathogenesis of spondyloarthritis continues
to be an important goal. Current efforts are aimed largely on three areas of investigation; …

Spondyloarthritis (SpA) refers to a group of diseases with inflammation in joints and spines.
In this family, ankylosing spondylitis (AS) is a rare but classic form that mainly involves the …

Heritability of Spondyloarthritis (SpA) is highlighted by several familial studies and a high
association with the presence of human leukocyte antigen (HLA)-B* 27. Though it has been …

Rheumatic diseases represent a heterogeneous group of inflammatory conditions, many of
which involve chronic activation of both innate and adaptive immune responses by multiple …

Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form
of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood …

The mechanism by which HLA-B* 27 predisposes to spondyloarthritis remains unresolved.
Arthritogenic peptides have not been defined in humans and are not involved in …

Subclinical inflammation is associated with Spondylarthritis (SpA). SpA patients show
features of dysbiosis, altered gut barrier function, and local expansion of innate and innate …

The inflammatory interleukin (IL)-23/IL-17 axis plays an important role in the pathogenesis of
ankylosing spondylitis (AS), but with an unknown regulatory mechanism. This study aimed to …