The role of insulin-like growth factor-1 (IGF-1) in the control of neuroendocrine regulation of growth
S Al-Samerria, S Radovick - Cells, 2021 - mdpi.com
In mammals, the neuroendocrine system, which includes the communication between the
hypothalamus and the pituitary, plays a major role in controlling body growth and cellular …
hypothalamus and the pituitary, plays a major role in controlling body growth and cellular …
Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer
Since its discovery nearly a century ago, over 100,000 studies of growth hormone (GH) have
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …
[HTML][HTML] The hypertrophic chondrocyte: To be or not to be.
Hypertrophic chondrocytes are the master regulators of endochondral ossification; however,
their ultimate cell fates cells remain largely elusive due to their transient nature. Historically …
their ultimate cell fates cells remain largely elusive due to their transient nature. Historically …
Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan
Studies in multiple species indicate that reducing growth hormone (GH) action enhances
healthy lifespan. In fact, GH receptor knockout (GHRKO) mice hold the Methuselah prize for …
healthy lifespan. In fact, GH receptor knockout (GHRKO) mice hold the Methuselah prize for …
Effect of growth hormone on insulin signaling
Growth hormone (GH) is a pleiotropic hormone that coordinates an array of physiological
processes, including effects on bone, muscle, and fat, ultimately resulting in growth …
processes, including effects on bone, muscle, and fat, ultimately resulting in growth …
Mice with gene alterations in the GH and IGF family
Much of our understanding of GH's action stems from animal models and the generation and
characterization of genetically altered or modified mice. Manipulation of genes in the …
characterization of genetically altered or modified mice. Manipulation of genes in the …
Adipose tissue and endocrine-disrupting chemicals: does sex matter?
B Le Magueresse-Battistoni - … of environmental research and public health, 2020 - mdpi.com
Obesity and metabolic-related diseases, among which diabetes, are prominent public health
challenges of the 21st century. It is now well acknowledged that pollutants are a part of the …
challenges of the 21st century. It is now well acknowledged that pollutants are a part of the …
Exploring the therapeutic potential of targeting GH and IGF-1 in the management of obesity: Insights from the interplay between these hormones and metabolism
S Al-Samerria, S Radovick - International journal of molecular sciences, 2023 - mdpi.com
Obesity is a growing public health problem worldwide, and GH and IGF-1 have been studied
as potential therapeutic targets for managing this condition. This review article aims to …
as potential therapeutic targets for managing this condition. This review article aims to …
Fight against fibrosis in adipose tissue remodeling
S Li, H Gao, Y Hasegawa, X Lu - American Journal of …, 2021 - journals.physiology.org
Adipose is a key tissue regulating energy homeostasis. In states of obesity, caloric intake
exceeds energy expenditure, thereby accelerating lipid accumulation with ongoing …
exceeds energy expenditure, thereby accelerating lipid accumulation with ongoing …
Growth hormone deficiency and excess alter the gut microbiome in adult male mice
EA Jensen, JA Young, Z Jackson, J Busken… - …, 2020 - academic.oup.com
The gut microbiome has been implicated in host metabolism, endocrinology, and
pathophysiology. Furthermore, several studies have shown that gut bacteria impact host …
pathophysiology. Furthermore, several studies have shown that gut bacteria impact host …