In the last decades, evidence suggesting the direct or indirect involvement of B cells on
multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

Multiple sclerosis is a chronic disease of the CNS that leads to substantial disability in most
patients. The early phase is characterised by relapses and the later phase by progressive …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …

Meningeal inflammation in the form of ectopic lymphoid-like structures has been suggested
to play a prominent role in the development of cerebral cortical grey matter pathology in …

Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-
bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ …

Substantial advances have elucidated some of the central mechanisms underlying the
inflammation, demyelination, and neurodegeneration that occur in multiple sclerosis …

Intrathecal antibody production is a hallmark of multiple sclerosis and humoral immunity is
thought to play an important role in the inflammatory response and development of …

Multiple sclerosis (MS) is characterized by synthesis of oligoclonal immunoglobulins and the
presence of B‐cell clonal expansions in the central nervous system (CNS). Because ectopic …

Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, has been associated
with multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS) …