Clinical overview of MDM2/X-targeted therapies
MDM2 and MDMX are the primary negative regulators of p53, which under normal
conditions maintain low intracellular levels of p53 by targeting it to the proteasome for rapid …
conditions maintain low intracellular levels of p53 by targeting it to the proteasome for rapid …
Cell-penetrating peptides (CPPs): An overview of applications for improving the potential of nanotherapeutics
In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell
continues to be an ultimate challenge. There are many physicochemical factors such as …
continues to be an ultimate challenge. There are many physicochemical factors such as …
Recent advances in the use of cell-penetrating peptides for medical and biological applications
SB Fonseca, MP Pereira, SO Kelley - Advanced drug delivery reviews, 2009 - Elsevier
The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …
gaining cellular access. Since many therapeutics and reporter molecules must be …
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
MS Dai, SX Zeng, Y Jin, XX Sun… - Molecular and cellular …, 2004 - Am Soc Microbiol
The p53-MDM2 feedback loop is vital for cell growth control and is subjected to multiple
regulations in response to various stress signals. Here we report another regulator of this …
regulations in response to various stress signals. Here we report another regulator of this …
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
S Kurki, K Peltonen, L Latonen, TM Kiviharju, PM Ojala… - Cancer cell, 2004 - cell.com
Abstract Nucleophosmin (NPM, B23) is an abundant nucleolar phosphoprotein involved in
ribosome biogenesis, and interacts with tumor suppressor proteins p53 and Rb. Here we …
ribosome biogenesis, and interacts with tumor suppressor proteins p53 and Rb. Here we …
The multiple levels of regulation by p53 ubiquitination
Abstract p53 is a central integrator of a plethora of signals and outputs these signals in the
form of tumor suppression. It is well accepted that ubiquitination plays a major part in p53 …
form of tumor suppression. It is well accepted that ubiquitination plays a major part in p53 …
p53-independent functions of the p19ARF tumor suppressor
The p19ARF tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle
arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop …
arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop …
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function
C Korgaonkar, J Hagen, V Tompkins… - … and cellular biology, 2005 - Taylor & Francis
The ARF tumor suppressor is a nucleolar protein that activates p53-dependent checkpoints
by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and …
by binding Mdm2, a p53 antagonist. Despite persuasive evidence that ARF can bind and …
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
S Llanos, PA Clark, J Rowe, G Peters - Nature cell biology, 2001 - nature.com
The alternative product of the human INK4a/ARF locus, p14 ARF, has the potential to act as
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
[HTML][HTML] Identification of a ubiquitin–protein ligase subunit within the CCR4–NOT transcription repressor complex
TK Albert, H Hanzawa, YIA Legtenberg… - The EMBO …, 2002 - embopress.org
The RING finger protein CNOT4 is a component of the CCR4–NOT complex. This complex is
implicated in repression of RNA polymerase II transcription. Here we demonstrate that …
implicated in repression of RNA polymerase II transcription. Here we demonstrate that …