Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
The neuroanatomical–functional paradox in spinal cord injury
Although lesion size is widely considered to be the most reliable predictor of outcome after
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …
Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …
can be observed with MRI techniques. These techniques provide sensitive markers of …
MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers
Traumatic spinal cord injury occurs when an external physical impact damages the spinal
cord and leads to permanent neurological dysfunction and disability, and it is associated …
cord and leads to permanent neurological dysfunction and disability, and it is associated …
[HTML][HTML] Guidelines for the conduct of clinical trials in spinal cord injury: Neuroimaging biomarkers
M Seif, CAM Gandini Wheeler-Kingshott… - Spinal Cord, 2019 - nature.com
Traumatic spinal cord injury (SCI) leads to immediate neuronal and axonal damage at the
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …
focal injury site and triggers secondary pathologic series of events resulting in sensorimotor …
[HTML][HTML] Finger somatotopy is preserved after tetraplegia but deteriorates over time
Previous studies showed reorganised and/or altered activity in the primary sensorimotor
cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However …
cortex after a spinal cord injury (SCI), suggested to reflect abnormal processing. However …
[HTML][HTML] Spinal cord imaging markers and recovery of volitional leg movement with spinal cord epidural stimulation in individuals with clinically motor complete spinal …
Previous studies have shown that epidural stimulation of the lumbosacral spinal cord (scES)
can re-enable lower limb volitional motor control in individuals with chronic, clinically motor …
can re-enable lower limb volitional motor control in individuals with chronic, clinically motor …
Predictive value of midsagittal tissue bridges on functional recovery after spinal cord injury
Background The majority of patients with spinal cord injury (SCI) have anatomically
incomplete lesions and present with preserved tissue bridges, yet their outcomes vary …
incomplete lesions and present with preserved tissue bridges, yet their outcomes vary …
Longitudinal changes of spinal cord grey and white matter following spinal cord injury
Objectives Traumatic and non-traumatic spinal cord injury produce neurodegeneration
across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and …
across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and …
Stimulation of the cuneiform nucleus enables training and boosts recovery after spinal cord injury
AS Hofer, MI Scheuber, AM Sartori, N Good, SA Stalder… - Brain, 2022 - academic.oup.com
Severe spinal cord injuries result in permanent paraparesis in spite of the frequent sparing
of small portions of white matter. Spared fibre tracts are often incapable of maintaining and …
of small portions of white matter. Spared fibre tracts are often incapable of maintaining and …