Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019

D Singh, A Agusti, A Anzueto, PJ Barnes… - European …, 2019 - Eur Respiratory Soc
Precision medicine is a patient-specific approach that integrates all relevant clinical, genetic
and biological information in order to optimise the therapeutic benefit relative to the …

Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact

M MacLeod, A Papi, M Contoli, B Beghé, BR Celli… - …, 2021 - Wiley Online Library
In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized
by an acute deterioration in respiratory symptoms, are fundamental events impacting …

Pharmacologic management of chronic obstructive pulmonary disease. An official American Thoracic Society clinical practice guideline

L Nici, MJ Mammen, E Charbek… - American journal of …, 2020 - atsjournals.org
Background: This document provides clinical recommendations for the pharmacologic
treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative …

Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials

M Bafadhel, S Peterson, MA De Blas… - The Lancet …, 2018 - thelancet.com
Background The peripheral blood eosinophil count might help identify those patients with
chronic obstructive pulmonary disease (COPD) who will experience fewer exacerbations …

Exacerbations of COPD

C Viniol, CF Vogelmeier - European Respiratory Review, 2018 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide. While COPD is a mainly chronic disease, a substantial number of patients suffer …

Inflammatory endotypes in COPD

PJ Barnes - Allergy, 2019 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a major global health problem that is
poorly treated by current therapies as it has proved difficult to treat the underlying …

Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review

CM Riley, FC Sciurba - Jama, 2019 - jamanetwork.com
Importance There are 30 million adults (12%) in the United States who have chronic
obstructive pulmonary disease (COPD). Chronic obstructive pulmonary disease accounts for …

Inhaled corticosteroids in COPD: friend or foe?

A Agusti, LM Fabbri, D Singh, J Vestbo… - European …, 2018 - Eur Respiratory Soc
The efficacy, safety and positioning of inhaled corticosteroids (ICS) in the treatment of
patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can …

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

AT Hastie, FJ Martinez, JL Curtis… - The Lancet …, 2017 - thelancet.com
Background Increased concentrations of eosinophils in blood and sputum in chronic
obstructive pulmonary disease (COPD) have been associated with increased frequency of …

Long-term triple therapy de-escalation to indacaterol/glycopyrronium in patients with chronic obstructive pulmonary disease (SUNSET): a randomized, double-blind …

KR Chapman, JR Hurst, SM Frent, M Larbig… - American journal of …, 2018 - atsjournals.org
Rationale: There are no studies on withdrawal of inhaled corticosteroids in patients on long-
term triple therapy in the absence of frequent exacerbations. Objectives: To evaluate the …