TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Tolerogenic dendritic cells in autoimmunity and inflammatory diseases
O Morante-Palacios, F Fondelli, E Ballestar… - Trends in …, 2021 - cell.com
Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …
Sensitivity of transcription factors to DNA methylation
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …
states throughout organism development. Epigenetics modifications, such as DNA …
β-Glucan reverses the epigenetic state of LPS-induced immunological tolerance
Innate immune memory is the phenomenon whereby innate immune cells such as
monocytes or macrophages undergo functional reprogramming after exposure to microbial …
monocytes or macrophages undergo functional reprogramming after exposure to microbial …
Active DNA demethylation promotes cell fate specification and the DNA damage response
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …
Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate
Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
O Morante-Palacios, G Godoy-Tena… - Nucleic acids …, 2022 - academic.oup.com
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …
activation of naïve T cells. DCs' immunological properties are modulated in response to …
[HTML][HTML] Tet2 restrains inflammatory gene expression in macrophages
Tet methylcytosine dioxygenase 2 (TET2) is one of the earliest and most frequently mutated
genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers …
genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers …
Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: the children's environmental health and disease …
Background: Characterization of the epigenome is a primary interest for children's
environmental health researchers studying the environmental influences on human …
environmental health researchers studying the environmental influences on human …
Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …