Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

The steroid hormone 17ß-estradiol (E2) is a key regulator of growth, differentiation, and
function in a wide array of target tissues, including the male and female reproductive tracts …

There is now a large body of evidence suggesting that the decline in ovarian function with
menopause is associated with spontaneous increases in proinflammatory cytokines. The …

The selective estrogen-receptor modulators, or SERMs, chemically diverse nonsteroid
compounds, have tertiary structures that permit binding to the estrogen receptor. These …

Estrogens are known to be important in the growth of breast cancers in both pre and
postmenopausal women. As the number of breast cancer patients increases with age, the …

Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal
compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target …

The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in natural
products (such as the anticoagulant warfarin) that display interesting pharmacological …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Although it has been known for many years that estrogen administration has deleterious
effects on male fertility, data from transgenic mice deficient in estrogen receptors or …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …