Targeting oxidative stress mechanisms to treat Alzheimer's and Parkinson's disease: a critical review

AT Aborode, M Pustake, WA Awuah… - Oxidative medicine …, 2022 - Wiley Online Library
Neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease
(PD) are becoming more frequent as the age increases. Contemporary therapies provide …

Positive aspects of oxidative stress at different levels of the human body: A review

G Jîtcă, BE Ősz, A Tero-Vescan, AP Miklos, CM Rusz… - Antioxidants, 2022 - mdpi.com
Oxidative stress is the subject of numerous studies, most of them focusing on the negative
effects exerted at both molecular and cellular levels, ignoring the possible benefits of free …

The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response

BN Puente, W Kimura, SA Muralidhar, J Moon… - Cell, 2014 - cell.com
The mammalian heart has a remarkable regenerative capacity for a short period of time after
birth, after which the majority of cardiomyocytes permanently exit cell cycle. We sought to …

Mitochondria, metabolism, and redox mechanisms in psychiatric disorders

Y Kim, KC Vadodaria, Z Lenkei, T Kato… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …

NOX enzymes in the central nervous system: from signaling to disease

S Sorce, KH Krause - Antioxidants & redox signaling, 2009 - liebertpub.com
Oxidative stress has been implicated in the pathogenesis of neurologic and psychiatric
diseases. The brain is particularly vulnerable to oxidative damage due to high oxygen …

[HTML][HTML] Function of reactive oxygen species during animal development: passive or active?

L Covarrubias, D Hernández-García, D Schnabel… - Developmental …, 2008 - Elsevier
Oxidative stress is considered causal of aging and pathological cell death, however, very
little is known about its function in the natural processes that support the formation of an …

Reactive oxygen species: angels and demons in the life of a neuron

K Biswas, K Alexander, MM Francis - NeuroSci, 2022 - mdpi.com
Reactive oxygen species (ROS) have emerged as regulators of key processes supporting
neuronal growth, function, and plasticity across lifespan. At normal physiological levels, ROS …

Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

WC Ballance, EC Qin, HJ Chung, MU Gillette, H Kong - Biomaterials, 2019 - Elsevier
Neurodegenerative diseases and disorders seriously impact memory and cognition and can
become life-threatening. Current medical techniques attempt to combat these detrimental …

Polydopamine nanoparticles as an organic and biodegradable multitasking tool for neuroprotection and remote neuronal stimulation

M Battaglini, A Marino, A Carmignani… - … applied materials & …, 2020 - ACS Publications
Oxidative stress represents a common issue in most neurological diseases, causing severe
impairments of neuronal cell physiological activity that ultimately lead to neuron loss of …