Human pluripotent stem cells as a translational toolkit in psychedelic research in vitro
JA Salerno, S Rehen - Iscience, 2024 - cell.com
Psychedelics, recognized for their impact on perception, are resurging as promising
treatments with rapid onset for mood and substance use disorders. Despite increasing …
treatments with rapid onset for mood and substance use disorders. Despite increasing …
[HTML][HTML] Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing
C Cervetto, F Pistollato, S Amato… - Reproductive …, 2023 - Elsevier
Human induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) and their
differentiated neuronal/glial derivatives have been recently considered suitable to assess in …
differentiated neuronal/glial derivatives have been recently considered suitable to assess in …
Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration
TJY Birkle, HMG Willems, J Skidmore, GC Brown - Iscience, 2024 - cell.com
Neuropathology is often mediated by interactions between neurons and glia that cannot be
modeled by monocultures. However, cocultures are difficult to use and analyze for high …
modeled by monocultures. However, cocultures are difficult to use and analyze for high …
Glutamate secretion by embryonic stem cells as an autocrine signal to promote proliferation
L Teng, Q Qin, Z Zhou, F Zhou, C Cao, J Yang… - Scientific Reports, 2023 - nature.com
Glutamate, the major excitatory neurotransmitter in the central nervous system, has also
been found to play a role in embryonic stem (ES) cells. However, the exact mechanism and …
been found to play a role in embryonic stem (ES) cells. However, the exact mechanism and …
[HTML][HTML] Generation of IGGi003-A induced pluripotent stem cell line from a patient with Sotos Syndrome carrying c. 1633delA NSD1 variant in exon 5
G Conteduca, C Baldo, A Arado, JSM da Silva… - Stem Cell Research, 2024 - Elsevier
Sotos syndrome (SoS) is a neurodevelopmental disorder that results from NSD1 mutations
that cause haploinsufficiency of NSD1. Here, we generated an induced pluripotent stem cell …
that cause haploinsufficiency of NSD1. Here, we generated an induced pluripotent stem cell …
[HTML][HTML] Generation of induced pluripotent stem cell lines from a patient with Sotos syndrome carrying 5q35 microdeletion
G Conteduca, C Baldo, A Arado, M Traverso, B Testa… - Stem Cell Research, 2023 - Elsevier
Sotos syndrome (SoS) is a neurodevelopmental disorder caused by haploinsufficiency of
the NSD1 gene located on chromosome 5 region q35. 3. In order to understand the …
the NSD1 gene located on chromosome 5 region q35. 3. In order to understand the …
Genetic and Molecular Dissection of the Corkscrew Phosphatase in Synaptic Function and Neurological Disease
SN Leahy - 2024 - ir.vanderbilt.edu
Cytoplasmic protein tyrosine phosphatase non-receptor type 11 (PTPN11) and Drosophila
homolog Corkscrew (Csw) regulate the mitogen-activated protein kinase (MAPK) pathway …
homolog Corkscrew (Csw) regulate the mitogen-activated protein kinase (MAPK) pathway …
hiPSC-Derived Cells as Models for Drug Discovery 2.0
R Ofir - International Journal of Molecular Sciences, 2023 - mdpi.com
Human-induced pluripotent stem cells (hiPSCs) serve as a sustainable resource for studying
the molecular foundation of disease development, including initiation and deterioration …
the molecular foundation of disease development, including initiation and deterioration …