As important physiological regulators, peptides have been used in many fields including
medicine, cosmetics, healthcare products, animal nutrition and health, and plant nutrition …

Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …

Poisonous organisms are represented in many taxa, including kingdom Animalia. During
evolution, animals have developed special organs for production and injection of venoms …

Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

According to the 2020 data released by the International Agency for Research on Cancer,
breast cancer has surpassed lung cancer as the world's most newly diagnosed first-time …

Nicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate
neurotransmission. However, their widespread distribution in the human body suggests a …

αO-Conotoxin GeXIVA is a selective α9α10 nicotinic acetylcholine receptor (nAChR)
inhibitor displaying two disulfide bonds that can form three isomers. The bead (GeXIVA [1 …

The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …

Abstract α-Conotoxins are disulfide-rich and well-structured peptides, most of which can
block nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency …