Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …

Membrane traffic in eukaryotic cells is mediated by transport vesicles that bud from a
precursor compartment and are transported to their destination compartment where they …

Intracellular trafficking entails the budding, transport, tethering, and fusion of transport
vesicles and other membrane carriers. Here we review recent progress toward a …

Transport of material within cells is mediated by trafficking vesicles that bud from one cellular
compartment and fuse with another. Formation of a trafficking vesicle is driven by membrane …

Secretion is the cellular process present in every organism that delivers soluble proteins and
cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the …

COPI‐coated vesicles mediate transport between Golgi stacks and retrograde transport from
the Golgi to the endoplasmic reticulum. The COPI coat exists as a stable heptameric …

The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between
Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the …

Protein trafficking within eukaryotic cells depends on vesicular carriers that fuse with
organelles to deliver their lipid and protein content. Cells have developed an elaborate …