Phencyclidine (PCP) has recently been shown to induce apoptosis of a subpopulation of
striatopallidal neurons which lie in the dorsomedial caudate–putamen. The pharmacological …

Recent evidence suggests that modulation of dopaminergic transmission alters striatal
levels of extracellular adenosine. The present study used reverse microdialysis of the …

For several years, quantitative in situ hybridization has emerged as a particularly powerful
technique to study gene expression within complex heterocellular systems, including the …

Fenfluramine (FE) is a halogenated amphetamine derivative that has been used in the
treatment of obesity. It has been suggested that the effects of FE on the striatum are …

Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that
originates from the breakdown of ATP. By binding to its four receptor subtypes (A 1, A 2A, A …

Adenosine A2A receptors are Golf-coupled receptors and are predominantly expressed in
the striatum of mammalian brains. As a mostly postsynaptic receptor, A2A receptors are …

Recent years have seen an explosion of activity in the field of biomedical imaging in an
attempt to understand the behavior of the brain in healthy and disease states. With the …

Phencyclidine (PCP), a non-competitive antagonist of the NMDA subtype of glutamate
receptor, which also acts as an indirect dopamine agonist and at sigma sites, can induce a …

Cholinergic transmission regulates many behavioural domains, ranging from motor activity
to cognition. Acetylcholine signalling is mediated by muscarinic and nicotinic acetylcholine …

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is produced by GABAergic
neurons and is essential in human neurodevelopmental stage. It has a variety of functions in …