Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and
the diseases it causes, with transient expression of nuclear reprogramming factors recently …

Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

Although oxidative phosphorylation is best known for producing ATP, it also yields reactive
oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological …

Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …

The epigenetic mechanisms that maintain differentiated cell states remain incompletely
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …

Pluripotency is highly dynamic and progresses through a continuum of pluripotent stem cell
states. The two states that bookend the pluripotency continuum, naive and primed, are well …

Brain expressed X-linked gene 2 (BEX2) encoded protein was originally identified to
promote transcription by interacting with several transcription factors in the DNA–binding …

Transcription factor (TF)-induced reprogramming of somatic cells across lineages and to
induced pluripotent stem cells (iPSCs) has revealed a remarkable plasticity of differentiated …

The interplay between the Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) and
transcriptional/epigenetic co-regulators in somatic cell reprogramming is incompletely …