There is great need for stand-alone luminescence-based chemosensors that exemplify
selectivity, sensitivity, and applicability and that overcome the challenges that arise from …

AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Cells translate extracellular signals to regulate processes such as differentiation,
metabolism and proliferation, via transmembranar receptors. G protein-coupled receptors …

Background: Suicide rates are high among older adults and many conditions have been
related to suicide in this population: chronic illnesses, physical disabilities, cancer, social …

A library of eighteen thienocycloalkylpyridazinones was synthesized for human
acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) inhibition and serotonin 5 …

Since the last century, when scientists proposed the lock-and-key model, the discovery of
drugs has focused on the development of drugs acting on single target. However, single …

The hippocampal region receives a dense serotoninergic innervation originating from both
medial and dorsal raphe nuclei. This innervation regulates hippocampal activity through the …

Alzheimer's disease (AD) is a neurodegenerative disorder and neuropathologically
characterized by the aggregation of amyloid-beta (Aβ) plaques, neurofibrillary tangles …

Serotonin receptors are involved in a number of physiological functions and regulate
aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and …