Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …

Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-
mediated infiltration and a destruction of the aortic wall during AAA development plays …

Cardiovascular diseases are the first leading cause of death and morbidity in developed
countries. The use of animal models have contributed to increase our knowledge, providing …

The renin-angiotensin system (RAS) is an important therapeutic target in the treatment of
hypertension. Obesity has emerged as a primary contributor to essential hypertension in the …

Rationale: We have previously found that T lymphocytes are essential for development of
angiotensin II–induced hypertension; however, the mechanisms responsible for T-cell …

Background Identifying effective drugs to suppress vascular inflammation is a promising
strategy to delay the progression of abdominal aortic aneurysm (AAA). Itaconate has a vital …

Abstract Aims Angiotensin II (AngII) is a potential contributor to the development of
abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells (VSMCs) …

Previous trials indicate that surgical management of small abdominal aortic aneurysms
(AAA) does not reduce mortality. The medical management of AAA, however, has to a large …

Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due
to medial disruption and results in luminal dilation and thrombus formation. The objective of …

The AT 1 receptor, a major effector of the renin-angiotensin system, has been extensively
studied in the context of cardiovascular and renal disease. Moreover, angiotensin receptor …