Neuroinflammation is instigated by the misfiring of immune cells in the central nervous
system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Although the pathological contributions of reactive astrocytes have been implicated in
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …

Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain
functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis …

In the last decade, positron emission tomography (PET) and single-photon emission
computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the …

The molecular mediators of cell death and inflammation in Alzheimer's disease (AD) have
yet to be fully elucidated. Caspase-8 is a critical regulator of several cell death and …

Alzheimer's disease, which is the most common form of dementia, is characterized by the
aggregation of the amyloid β peptide (Aβ) and by an impairment of calcium homeostasis …

Background: In vivo PET/SPECT imaging of neuroinflammation is primarily based on the
estimation of the 18kDatranslocator-protein (TSPO). However, TSPO is expressed by …

N-Palmitoylethanolamide (PEA) is a non-endocannabinoid lipid mediator belonging to the
class of the N-acylethanolamine phospolipids and was firstly isolated from soy lecithin, egg …

The effect of Alzheimer's disease (AD) medications on CD4+ T cells homing has not been
thoroughly investigated. CD4+ T cells could both exacerbate and reduce AD symptoms …