Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder, is characterized by severe cognitive decline and personality changes as a result of …

Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs),
were first described. Like other members of the nuclear receptors superfamily, PPARs have …

The NMDA receptor (R) plays important roles in brain physiology and pathology as an ion
channel. Here we examine the ion flow-independent coupling of agonist to the NMDAR …

Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for
the regulation of actin reorganization in response to various signals. Accumulating evidence …

Alzheimer's disease (AD) is a global public health priority as with aging populations, its
prevalence is expected to rise even further in the future. The brain and gut are in close …

Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal
excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to …

Introduction Alzheimer's disease (AD) symptoms reflect synaptic dysfunction and neuron
death. Amyloid-β oligomers (AβOs) induce excess calcium entry into neurons via N-methyl …

Alzheimer's disease (AD) is the most common form of dementia, most prevalent in the
elderly population and has a significant impact on individuals and their family as well as the …

Impaired synaptic plasticity is implicated in the functional decline of the nervous system
associated with ageing. Understanding the structure of ageing synapses is essential to …

Aging is the most important risk factor associated with Alzheimer's disease (AD); however,
the molecular mechanisms linking aging to AD remain unclear. Suppression of the …