Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …

Background The most common type of monogenic diabetes is maturity-onset diabetes of the
young (MODY), a clinically and genetically heterogeneous group of endocrine disorders that …

Broad heterogeneity in pancreatic β-cell function and morphology has been widely reported.
However, determining which components of this cellular heterogeneity serve a diabetes …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Over the last two decades, improved access to human islets and the development of human
islet distribution networks have enabled the use of millions of human islets in hundreds of …

Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …

Diabetes, a disease characterized by hyperglycemia, has a serious impact on the lives and
families of patients as well as on society. Diabetes is a group of highly heterogeneous …

For the past 70 years, controversy about hypoglycemia in newborn infants has focused on a
numerical “definition of neonatal hypoglycemia”, without regard to its mechanism. This …

Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3
(MODY3), characterized by insulin secretion defects. However, specific mechanisms of …

Both basal and glucose-stimulated insulin release occur primarily by insulin secretory
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …