The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined.
Previously, we delineated the critical role of the control of extracellular matrix (ECM) …

Serpin family E member 1 (SERPINE1), a serine proteinase inhibitor, serves as an important
regulator of extra-cellular matrix remodeling. Emerging evidence suggests that SERPINE1 …

Abstract Yes-associated protein 1 (YAP1), the core effector of the Hippo signaling pathway,
has been identified as a key regulator of tissue homeostasis and organ development by …

We and others have shown that the Hippo pathway effectors TAZ and YAP direct Smad
activity to regulate TGFβ family-induced cellular responses in stem cell and cancer biology …

Endothelial-to-mesenchymal transition (EndMT) is the biological process through which
endothelial cells transdifferentiate into mesenchymal cells. During embryo development …

Malignant pleural mesothelioma (MPM) is a lethal and rare cancer, even if its incidence has
continuously increased all over the world. Asbestos exposure leads to the development of …

Although YAP-dependent transcription is closely associated with liver tumorigenesis, the
mechanism by which YAP maintains its function is poorly understood. Here, we show that …

Stress in the heart causes loss of cardiomyocytes (CMs), the accumulation of which leads to
heart failure, a major cause of clinical mortality. The improvement of CM survival and …

Idiopathic pulmonary fibrosis is a life-threatening progressive disease characterized by loss
of alveolar epithelial cells, inflammation, and aberrant fibroblast activation. The two currently …

Caudal fin regeneration is characterized by a proliferation boost in the mesenchymal
blastema that is controlled precisely in time and space. This allows a gradual and robust …