Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …

Inflammation is ubiquitous in the body, triggering desirable immune response to defend
against dangerous signals or instigating undesirable damage to cells and tissues to cause …

Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …

Sepsis represents an important global health burden due to its high mortality and morbidity.
The rapid detection of sepsis is crucial in order to prevent adverse outcomes and reduce …

We investigated the contribution of human platelets to macrophage effector properties in the
presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for …

Background COVID-19-associated acute respiratory distress syndrome (ARDS) is
associated with significant morbidity and high levels of mortality. This paper describes the …

Circulating platelets are responsible for hemostasis and thrombosis but are also primary
sensors of pathogens and are involved in innate immunity, inflammation, and sepsis. Sepsis …

Background Although both leukocytosis and leukopenia have been considered Systemic
Inflammatory Response Syndrome criteria, leukopenia is not generally considered a normal …

Sepsis is a major global health problem that results from a dysregulated and uncontrolled
host response to infection, causing organ failure. Despite effective anti-infective therapy and …