[HTML][HTML] Clinical trials in traumatic spinal cord injury
J Donovan, S Kirshblum - Neurotherapeutics, 2018 - Elsevier
Traumatic spinal cord injury (SCI) results in impaired neurologic function that for many
individuals is permanent and significantly impacts health, function, quality of life, and life …
individuals is permanent and significantly impacts health, function, quality of life, and life …
Pathophysiology of spinal cord injury
LD Hachem, MG Fehlings - Neurosurgery Clinics, 2021 - neurosurgery.theclinics.com
Spinal cord injury (SCI) triggers a complex cascade of molecular and chemical events that
leads to progressive cell loss and tissue damage. 1, 2 Nearly a century of fundamental basic …
leads to progressive cell loss and tissue damage. 1, 2 Nearly a century of fundamental basic …
Intramedullary lesion length on postoperative magnetic resonance imaging is a strong predictor of ASIA impairment scale grade conversion following decompressive …
BACKGROUND: Evidence indicates that, over time, patients with spinal cord injury (SCI)
improve neurologically in various degrees. We sought to further investigate indicators of …
improve neurologically in various degrees. We sought to further investigate indicators of …
Expansion duroplasty improves intraspinal pressure, spinal cord perfusion pressure, and vascular pressure reactivity index in patients with traumatic spinal cord injury …
We recently showed that, after traumatic spinal cord injury (TSCI), laminectomy does not
improve intraspinal pressure (ISP), spinal cord perfusion pressure (SCPP), or the vascular …
improve intraspinal pressure (ISP), spinal cord perfusion pressure (SCPP), or the vascular …
[HTML][HTML] Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled …
MG Fehlings, H Nakashima, N Nagoshi, DSL Chow… - Spinal cord, 2016 - nature.com
Background: Riluzole is a sodium channel-blocking agent used in treating amyotrophic
lateral sclerosis. It has been approved by the US Food and Drug Administration, Canadian …
lateral sclerosis. It has been approved by the US Food and Drug Administration, Canadian …
[HTML][HTML] Economic impact of traumatic spinal cord injuries in the United States
CH Merritt, MA Taylor, CJ Yelton… - Neuroimmunology and …, 2019 - ncbi.nlm.nih.gov
Individuals having sustained traumatic spinal cord injury (TSCI) in the United States are
living longer as compared to historical trends, thanks to an ever-evolving understanding of …
living longer as compared to historical trends, thanks to an ever-evolving understanding of …
[HTML][HTML] Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside
N Nagoshi, H Nakashima, MG Fehlings - Molecules, 2015 - mdpi.com
Spinal cord injury (SCI) is a devastating event resulting in permanent loss of neurological
function. To date, effective therapies for SCI have not been established. With recent progress …
function. To date, effective therapies for SCI have not been established. With recent progress …
Traumatic spinal cord injury
AA Rabinstein - Continuum: Lifelong Learning in Neurology, 2018 - journals.lww.com
Traumatic Spinal Cord Injury : CONTINUUM: Lifelong Learning in Neurology Account
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Ultra-early (< 12 hours) surgery correlates with higher rate of American Spinal Injury Association Impairment Scale conversion after cervical spinal cord injury
BACKGROUND Cervical spinal cord injury (SCI) is a devastating condition with very few
treatment options. It remains unclear if early surgery correlated with conversion of American …
treatment options. It remains unclear if early surgery correlated with conversion of American …
Update on critical care for acute spinal cord injury in the setting of polytrauma
Traumatic spinal cord injury (SCI) often occurs in patients with concurrent traumatic injuries
in other body systems. These patients with polytrauma pose unique challenges to clinicians …
in other body systems. These patients with polytrauma pose unique challenges to clinicians …