Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

Abstract TET (ten-eleven-translocation) proteins are Fe (ii)-and α-ketoglutarate-dependent
dioxygenases,, that modify the methylation status of DNA by successively oxidizing 5 …

Histone Modifications Form Epigenetic Regulatory Networks to Regulate Abiotic Stress
Response1 [OPEN] | Plant Physiology | Oxford Academic Skip to Main Content Advertisement …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

The expression of 'clock'genes occurs in all tissues, but especially in the suprachiasmatic
nuclei (SCN) of the hypothalamus, groups of neurons in the brain that regulate circadian …

Transcription factors comprise just over 7% of the human proteome and serve as
gatekeepers of cellular function, integrating external signal information into gene expression …

The MYC family of proteins is a group of basic‐helix‐loop‐helix‐leucine zipper transcription
factors that feature prominently in cancer. Overexpression of MYC is observed in the vast …

In angiosperms, flower development requires the combined action of the transcription factor
LEAFY (LFY) and the ubiquitin ligase adaptor F-box protein, UNUSUAL FLORAL ORGANS …