Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

Background Biomarkers that can predict the prognosis of colorectal cancer (CRC) patients
and that can stratify high-risk early stage patients from low-risk early stage patients are …

Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …

Altered epigenetic regulation is central to many human diseases, including cancer. Over the
past two decade, major advances have been made in our understanding of the role of …

Developments in the diagnosis and treatment of colorectal cancer (CRC) have been made
in the last decade, but the overall survival rate of patients with CRC has not improved …

Oxidative stress is a common feature of inflammation-driven cancers, and it promotes
genomic instability and aggressive tumour phenotypes. It is known that oxidative stress …

Activating enhancer-binding protein 2 (AP-2) is a family of transcription factors (TFs) that
play crucial roles in regulating embryonic and oncogenic development. In addition to splice …

Chemotherapy is a mainstay of therapy for advanced gastric cancer (GC); however, owing to
drug resistances, the effectiveness of chemotherapy is not satisfactory for some patients with …

Background and Aims. Many studies have focused on the determination of methylated
targets in colorectal cancer. However, few analyzed the progressive methylation in the …