Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

S-nitrosylation is a selective and reversible post-translational modification of protein thiols by
nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These …

Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-
cysteinylglycine and the predominant intracellular antioxidant in many organisms including …

Nitric oxide, carbon monoxide and hydrogen sulfide are three endogenous gasotransmitters
that serve a role in regulating normal and pathological cellular activities. They can stimulate …

Nitric oxide (NO) has a wide range of potential applications in tumor therapy. However, a
targeted delivery system for NO donors has remained elusive, creating a bottleneck that …

Nitric oxide (NO) and hydrogen sulfide (H 2 S) are industrial toxins or pollutants; however,
both are produced endogenously and have important biological roles in most mammalian …

The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular
proteins. Targeting protein degradation has been validated as an effective strategy for …

Seven in absentia homolog 2 (Siah2), an RING E3 ubiquitin ligases, has been characterized
to play the vital role in tumorigenesis and cancer progression. Numerous studies have …

Nitric oxide (NO) is a ubiquitous signaling molecule in the human body with well-known
roles in many different processes and organ systems. In cancer, the two-concentrations …

Prostate cancer (PCa) is a malignant epithelial tumor of the prostate gland with a high male
cancer incidence. Numerous studies indicate that abnormal function of ubiquitin …