Respiratory syncytial virus infection and novel interventions

AC Langedijk, LJ Bont - Nature Reviews Microbiology, 2023 - nature.com
The large global burden of respiratory syncytial virus (RSV) respiratory tract infections in
young children and older adults has gained increased recognition in recent years. Recent …

Respiratory syncytial virus: infection, detection, and new options for prevention and treatment

C Griffiths, SJ Drews, DJ Marchant - Clinical microbiology reviews, 2017 - Am Soc Microbiol
Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children
in North America and one of the leading causes of death of infants less than 1 year of age …

Respiratory syncytial virus entry and how to block it

MB Battles, JS McLellan - Nature Reviews Microbiology, 2019 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in
young children and elderly people. Although the virus was isolated in 1955, an effective …

IGF1R is an entry receptor for respiratory syncytial virus

CD Griffiths, LM Bilawchuk, JE McDonough… - Nature, 2020 - nature.com
Pneumonia resulting from infection is one of the leading causes of death worldwide.
Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human …

Immunopathology of RSV: an updated review

HC Bergeron, RA Tripp - Viruses, 2021 - mdpi.com
RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …

The viral protein corona directs viral pathogenesis and amyloid aggregation

K Ezzat, M Pernemalm, S Pålsson, TC Roberts… - Nature …, 2019 - nature.com
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which
significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses …

Protective and harmful immunity to RSV infection

PJM Openshaw, C Chiu, FJ Culley… - Annual review of …, 2017 - annualreviews.org
Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in
infection of the ciliated respiratory epithelium, causing disease of variable severity with little …

[HTML][HTML] Respiratory syncytial virus: from pathogenesis to potential therapeutic strategies

Z Shang, S Tan, D Ma - International Journal of Biological Sciences, 2021 - ncbi.nlm.nih.gov
Respiratory syncytial virus (RSV) is one of the most important viral pathogens causing
respiratory tract infection in infants, the elderly and people with poor immune function, which …

Airway basal cells, protectors of epithelial walls in health and respiratory diseases

E Ruysseveldt, K Martens, B Steelant - Frontiers in Allergy, 2021 - frontiersin.org
The airway epithelium provides a critical barrier to the outside environment. When its
integrity is impaired, epithelial cells and residing immune cells collaborate to exclude …

Viral-bacterial co-infections in the cystic fibrosis respiratory tract

MR Kiedrowski, JM Bomberger - Frontiers in immunology, 2018 - frontiersin.org
A majority of the morbidity and mortality associated with the genetic disease Cystic Fibrosis
(CF) is due to lung disease resulting from chronic respiratory infections. The CF airways …