DNA forms not only the canonical duplex structure but also non-canonical structures. Most
potential sequences that induce the formation of non-canonical structures are present in …

Repetitive DNA sequences are abundant in eukaryotic genomes, and many of these
sequences have the potential to adopt non-B DNA conformations. Genes harboring non-B …

Naturally occurring DNA sequences can form noncanonical structures such as H-DNA,
which are abundant and regulate the expression of several disease-linked genes. Here, we …

A DNA duplex can be recognized sequence-specifically in the major groove by an
oligodeoxynucleotide (ODN). The resulting structure is a DNA triple helix, or triplex. The …

Analyses of chromosomal aberrations in human genetic disorders have revealed that
inverted repeat sequences (IRs) often co-localize with endogenous chromosomal instability …

Triplex-forming oligonucleotides (TFOs) can bind to polypurine/polypyrimidine regions in
DNA in a sequence-specific manner. The specificity of this binding raises the possibility of …

[Frontiers in Bioscience 13, 1064-1071, January 1, 2008] 1064 Discovery of alternative DNA
structures: a heroic decade (1979-198 Page 1 [Frontiers in Bioscience 13, 1064-1071 …

Inverted DNA repeats are an at-risk motif for genetic instability that can induce both deletions
and recombination in yeast. We investigated the role of the length of inverted repeats and …

Using computer programs developed for this purpose, we searched for various repeated
sequences including inverted, direct tandem, and homopurine–homopyrimidine mirror …

Investigation of i-motif is of high importance to fully understand the biological functions of G
quadruplexes in the context of double-stranded DNA. Whereas single-molecule approaches …