A novel interarm interaction of DNA cruciform forming at inverted repeat sequence was
characterized using an S1 nuclease digestion, permanganate oxidation, and microscopic …

A new cloning vector pN15L is described. It is a linear 13.8 kb plasmid based on the
coliphage N15 mini-replicon. The vector capacity exceeds 50 kb and the copy number is …

Structural variation of DNA within the promoter of the human Na, K-ATPase α2 gene, which
contains a 35-base pair (bp) homopyrimidine· homopurine (Py· Pu) tract adjacent to a TATA …

Background: Although most nucleotides in the genome form canonical double-stranded B-
DNA, many repeated sequences transiently present as non-canonical conformations (non-B …

Oligopyrimidine• oligopurine sequences with potential to form intramolecular triple helix
structures (H-DNA) have been found mainly in high eukaryote genomes. However, the …

Local structural transitions from the common B-DNA conformation into other DNA forms can
be functionally important. This chapter describes the structures of DNA forms called …

Recognition of sequences within duplex DNA is a general strategy for probing DNA function
and for disrupting gene expression. Peptide nucleic acids (PNAs) and conjugates between …

Modulation of endogenous gene function, through sequence-specific recognition of double
helical DNA via oligonucleotide-directed triplex formation, is a promising approach …

One of the fundamental characteristics of life is the ability of an entity to reproduce itself,
which stems from the ability of the DNA molecule to replicate itself. The initiation step of DNA …

In Saccharomyces cerevisiae, a-cell-specific genes are repressed in MAT α cells by
α2/Mcm1, acting in concert with the Ssn6-Tup1 corepressors and the Isw2 chromatin …