The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Osteoarthritis—the most common form of age-related degenerative whole-joint disease—is
primarily characterized by cartilage destruction, as well as by synovial inflammation …

Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such
as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

Background Research on the brain-gut-microbiota axis has led to accumulating interest in
gut microbiota dysbiosis and intestinal barrier dysfunction in Alzheimer's disease (AD). Our …

Non‐enzymatic and enzymatic oxidation of lipids has long been a primary issue in human
pathophysiology, with special emphasis on diet‐and nutrition‐related aspects. While there is …

Abstract The Liver X Receptors (LXRs) are oxysterol-activated transcription factors that
upregulate a suite of genes that together promote coordinated mobilization of excess …

The present review aims to provide a complete and comprehensive summary of current
literature relevant to oxysterols and related diseases. Oxidation of cholesterol leads to the …

Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid
molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids …