In the liver, biliary epithelial cells (BECs) line intrahepatic bile ducts (IHBDs) and are
primarily responsible for modifying and transporting hepatocyte-produced bile to the …

The formation of multiple cysts in the liver occurs in a number of isolated monogenic
diseases or multisystemic syndromes, during which bile ducts develop into fluid-filled biliary …

Polycystic kidney diseases are a group of monogenically inherited disorders characterized
by cyst development in the kidney with defects in primary cilia function central to …

Protein-truncating variants in α-1, 3-glucosyltransferase (ALG8) are a risk factor for a mild
cystic kidney disease phenotype. The association between these variants and liver cysts is …

α-1, 2-mannosyltransferase (ALG9) germline variants are linked to autosomal dominant
polycystic kidney disease (ADPKD). Many individuals affected with ADPKD possess …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited
kidney disease, which is characterized by progressive growth of multiple renal cysts in …

The Notch signalling pathway is an evolutionarily conserved mechanism of cell–cell
communication that mediates cellular proliferation, fate determination and maintenance of …

Objectives The purpose of this study was to examine the current literature on paediatric
COVID-19 vaccine hesitancy among parents and identify key influencing factors, thus …

Background & Aims Autosomal dominant polycystic liver disease is a rare condition with a
female preponderance, based mainly on pathogenic variants in 2 genes, PRKCSH and …

JMB),“Euskadi RIS3”(2019222054, 2020333010, 2022333032 to JMB). La Caixa Scientific
Foundation (HR17-00601 to JMB).“Fundación Científica de la Asociación Española Contra …