INTRODUCTION This review examines the concept of cognitive reserve (CR) in relation to
brain aging, particularly in the context of dementia and its early stages. CR refers to an …

Brain-derived neurotrophic factor signaling via its receptor tropomyosin receptor kinase B
regulates several crucial physiological processes. It has been shown to act in the brain …

Background: Developing effective strategies for reducing dementia risk requires a detailed
understanding of the risk and protective factors associated with the progression of mild …

The neuropathological mechanism of mild cognitive impairment (MCI) remains unclarified.
Diffusion tensor imaging (DTI) studies revealed white matter (WM) microarchitecture …

Both brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) have multiple roles
in the various aspects of neurons, including cell survival and synaptic function. BDNF and its …

Genetic factors underlie the pathological processes responsible for the manifestations of a
wide range of neurodegenerative diseases. The expansion of unstable trinucleotide repeats …

The present article delves into the complex correlation among neurotransmitter
dysregulation, antidepressant therapy, and Alzheimer's disease (AD). Progressive cognitive …

Генетические факторы лежат в основе патологических процессов, являющихся
причиной манифестации широкого круга нейродегенеративных заболеваний. В …

Neuropsychiatric symptoms (NPS) are common in Parkinson's disease (PD) and have
demonstrated an association with the p. Val66Met, a polymorphism in the BDNF gene. Mild …

Both major depression and subthreshold mood symptoms in older adults are associated
with an increased risk of cognitive decline and dementia. 1, 2 Unfortunately, treating …