Over the past 20 years great progress has been made in defining most of the key signalling
pathways that functionally regulate immune cells. Recently, it has become clear that scaffold …

The NF-κB family of transcription factors plays a crucial role in cell activation, survival and
proliferation. Its aberrant activity results in cancer, immunodeficiency or autoimmune …

Subcellular compartmentalization of macromolecules increases flux and prevents inhibitory
interactions to control biochemical reactions. Inspired by this functionality, we sought to build …

Adaptors are molecular scaffolds that recruit effectors, which are critical for immune cell
activation. Recent work has underscored the requirement for adaptors in propagating …

The scaffold protein Ste5 is required to properly direct signaling through the yeast mating
pathway to the mitogen-activated protein kinase (MAPK), Fus3. Scaffolds are thought to …

Many activities of cells are controlled by cell‐surface receptors, which in response to
ligands, trigger intracellular signaling reactions that elicit cellular responses. A hallmark of …

Motivation: We have used state-space models to reverse engineer transcriptional networks
from highly replicated gene expression profiling time series data obtained from a well …

IgE-dependent activation of mast cells is central to the allergic response. The engagement of
IgE-occupied receptors initiates a series of molecular events that cause the release of …

T cell antigen receptor (TCR) signaling in CD4+ CD8+ double-positive thymocytes
determines cell survival and lineage commitment, but the genetic and molecular basis of this …

Engagement of the T‐cell antigen receptor leads to recruitment of phospholipase Cγ1
(PLCγ1) to the LAT‐nucleated signaling complex and to PLCγ1 activation in a tyrosine …