Engineering the next generation of cell-based therapeutics

CJ Bashor, IB Hilton, H Bandukwala… - Nature Reviews Drug …, 2022 - nature.com
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

Clinical applications of stem cell-derived exosomes

F Tan, X Li, Z Wang, J Li, K Shahzad… - Signal Transduction and …, 2024 - nature.com
Although stem cell-based therapy has demonstrated considerable potential to manage
certain diseases more successfully than conventional surgery, it nevertheless comes with …

[HTML][HTML] Game changers in science and technology-now and beyond

UAK Betz, L Arora, RA Assal, H Azevedo… - … Forecasting and Social …, 2023 - Elsevier
The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …

Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Genetic engineering of T cells for immunotherapy

GI Ellis, NC Sheppard, JL Riley - Nature Reviews Genetics, 2021 - nature.com
Genetically engineered T cell immunotherapies have provided remarkable clinical success
to treat B cell acute lymphoblastic leukaemia by harnessing a patient's own T cells to kill …

Cell‐based delivery systems: emerging carriers for immunotherapy

Z Li, Y Wang, Y Ding, L Repp… - Advanced Functional …, 2021 - Wiley Online Library
Immunotherapy is leading a paradigm shift in the treatment of various diseases, including
tumors, auto‐immune diseases, and infectious diseases. However, the limited response rate …

Stem Cell‐Niche Engineering via Multifunctional Hydrogel Potentiates Stem Cell Therapies for Inflammatory Bone Loss

G Li, Z Li, L Li, S Liu, P Wu, M Zhou, C Li… - Advanced Functional …, 2023 - Wiley Online Library
Effective therapies capable of simultaneously inhibiting inflammation and promoting bone
healing remain to be developed for inflammatory bone disease. Stem cell therapies hold …

Regenerative approaches for the treatment of large bone defects

A Stahl, YP Yang - Tissue Engineering Part B: Reviews, 2021 - liebertpub.com
A variety of engineered materials have gained acceptance in orthopedic practice as
substitutes for autologous bone grafts, although the regenerative efficacy of these …

Polymeric materials, advances and applications in tissue engineering: a review

MC Socci, G Rodríguez, E Oliva, S Fushimi… - Bioengineering, 2023 - mdpi.com
Tissue Engineering (TE) is an interdisciplinary field that encompasses materials science in
combination with biological and engineering sciences. In recent years, an increase in the …

Bioinspired nanovesicles convert the skeletal endothelium-associated secretory phenotype to treat osteoporosis

Y Cui, Z Li, Y Guo, X Qi, Y Yang, X Jia, R Li, J Shi… - ACS …, 2022 - ACS Publications
Recently, bone marrow endothelial cells (BMECs) were found to play an important role in
regulating bone homeostasis. However, few studies utilized BMECs to treat bone metabolic …