Patients with chronic pain, especially orofacial pain, often suffer from affective disorders,
including anxiety. Previous studies largely focused on the role of the caudal anterior …

ABSTRACT BACKGROUND AND OBJECTIVES: Cognitive-behavioral approaches have
been applied in patients with chronic pain as a treatment strategy to reduce symptoms and …

Background. Meal ingestion induces a postprandial experience that involves homeostatic
and hedonic sensations. Our aim was to determine the effect of aversive conditioning on the …

Pain-related avoidance is adaptive when there is a bodily threat, but when it generalizes to
safe movements/situations, it may become disabling. Both subclinical anxiety—a …

Colloquial use of the term trauma brings together physical and mental distress, commonly
occurring together in maladaptive responses following threat and injury.“Trauma” is also …

Extinction-based protocols such as exposure-in-vivo successfully reduce pain-related fear in
chronic pain conditions, but return of fear and clinical relapse often occur …

Nocebo effects on pain are widely thought to be driven by negative expectations. This
suggests that anticipatory processing, or some other form of top-down cognitive activity prior …

Impaired extinction of pain-related fear memories can lead to persistent or resurging fear of
pain, contributing to the development and maintenance of chronic pain conditions. The …

Avoidance behavior is a key contributor to the transition from acute pain to chronic pain
disability. Yet, there has been a lack of ecologically valid paradigms to experimentally …

Pain-related learning mechanisms likely play a key role in the development and
maintenance of chronic pain. Previous smaller-scale studies have suggested impaired pain …