Cancer is one of the leading causes of death worldwide, and the factors responsible for its
progression need to be elucidated. Exosomes are structures with an average size of 100 nm …

Pancreatic ductal adenocarcinoma (PDAC) has one of the highest incidence/death ratios
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …

Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and
lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate …

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal
clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells …

Ras proteins are essential mediators of a multitude of cellular processes, and its
deregulation is frequently associated with cancer appearance, progression, and metastasis …

Considering the fact that cancer cells can switch among various molecular pathways and
mechanisms to ensure their progression, chemotherapy is no longer effective enough in …

Simple Summary Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor
(MET) signaling plays an important role in the metastatic formation and therapeutic …

Pancreatic cancer is characterized by hidden onset, high malignancy, and early metastasis.
Although a few cases meet the surgical indications, chemotherapy remains the primary …

Pancreatic cancer (PC) is known for its high degree of heterogeneity and exceptionally
adverse outcome. While disulfidptosis is the most recently identified form of cell death, the …

Pancreatic stellate cells play a pivotal role in the development of pancreatic fibrosis. A wide
variety of external stimuli can cause PSC activation accompanied by metabolic changes …