Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways

W Luo, Y Gu, S Fu, J Wang, J Zhang, Y Wang - European Journal of …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …

Idiopathic inflammatory myopathies: current insights and future frontiers

CM Connolly, L Gupta, M Fujimoto… - The Lancet …, 2024 - thelancet.com
Idiopathic inflammatory myopathies are a group of autoimmune diseases with a broad
spectrum of clinical presentations, primarily characterised by immune-mediated muscle …

Third-generation CD19. CAR-T cell-containing combination therapy in Scl70+ systemic sclerosis

W Merkt, M Freitag, M Claus, P Kolb… - Annals of the …, 2024 - ard.bmj.com
No effective treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD)
exists. Numerous evidences support the importance of adaptive immunity in SSc-ILD. A …

The Role of Inflammation and Fibrosis in Interstitial Lung Disease Treatment Decisions

J Behr, ML Salisbury, SLF Walsh… - American Journal of …, 2024 - atsjournals.org
Interstitial lung disease (ILD) is a large and heterogenous group of diseases, primarily
manifesting in the distal bronchoalveolar space. Some ILDs have identifiable causes or …

Evidence from recent clinical trials in fibrotic interstitial lung diseases

V Cottin, C Valenzuela - Current Opinion in Pulmonary Medicine, 2024 - journals.lww.com
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Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis

ER Volkmann, CP Denton, M Kolb… - European …, 2024 - Eur Respiratory Soc
Lysophosphatidic acid (LPA)-mediated activation of LPA receptor 1 (LPAR1) contributes to
the pathophysiology of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and …

Antifibrotic therapy in progressive pulmonary fibrosis: a review of recent advances

M Naqvi, J Hannah, A Lawrence, K Myall… - Expert Review of …, 2024 - Taylor & Francis
Introduction Progressive pulmonary fibrosis (PPF) is a manifestation of a heterogenous
group of underlying interstitial lung disease (ILD) diagnoses, defined as non-idiopathic …

Can we define difficult-to-treat systemic sclerosis?

G Szűcs, Z Szekanecz, S Szamosi - Expert Review of Clinical …, 2024 - Taylor & Francis
ABSTRACT Introduction Systemic sclerosis (SSc) is a chronic autoimmune rheumatic
disease characterized by microvascular alterations, immunopathology, and widespread …

Leukocyte telomere length: the dawn of a new era of personalised medicine in fibrotic interstitial lung diseases?

V Cottin, M Kolb - European Respiratory Journal, 2023 - Eur Respiratory Soc
Extract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrotic lung
disease of unknown cause [1]. Other types of pulmonary fibrosis may exhibit a phenotype of …

Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies

C Campochiaro, N Farina, G De Luca, V Batani… - Arthritis Research & …, 2024 - Springer
Introduction Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous
group diseases, and their treatment is not fully defined yet. According to previous small case …