Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
Idiopathic inflammatory myopathies: current insights and future frontiers
Idiopathic inflammatory myopathies are a group of autoimmune diseases with a broad
spectrum of clinical presentations, primarily characterised by immune-mediated muscle …
spectrum of clinical presentations, primarily characterised by immune-mediated muscle …
Third-generation CD19. CAR-T cell-containing combination therapy in Scl70+ systemic sclerosis
W Merkt, M Freitag, M Claus, P Kolb… - Annals of the …, 2024 - ard.bmj.com
No effective treatment of systemic sclerosis-associated interstitial lung disease (SSc-ILD)
exists. Numerous evidences support the importance of adaptive immunity in SSc-ILD. A …
exists. Numerous evidences support the importance of adaptive immunity in SSc-ILD. A …
The Role of Inflammation and Fibrosis in Interstitial Lung Disease Treatment Decisions
J Behr, ML Salisbury, SLF Walsh… - American Journal of …, 2024 - atsjournals.org
Interstitial lung disease (ILD) is a large and heterogenous group of diseases, primarily
manifesting in the distal bronchoalveolar space. Some ILDs have identifiable causes or …
manifesting in the distal bronchoalveolar space. Some ILDs have identifiable causes or …
Evidence from recent clinical trials in fibrotic interstitial lung diseases
V Cottin, C Valenzuela - Current Opinion in Pulmonary Medicine, 2024 - journals.lww.com
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Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis
ER Volkmann, CP Denton, M Kolb… - European …, 2024 - Eur Respiratory Soc
Lysophosphatidic acid (LPA)-mediated activation of LPA receptor 1 (LPAR1) contributes to
the pathophysiology of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and …
the pathophysiology of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and …
Antifibrotic therapy in progressive pulmonary fibrosis: a review of recent advances
M Naqvi, J Hannah, A Lawrence, K Myall… - Expert Review of …, 2024 - Taylor & Francis
Introduction Progressive pulmonary fibrosis (PPF) is a manifestation of a heterogenous
group of underlying interstitial lung disease (ILD) diagnoses, defined as non-idiopathic …
group of underlying interstitial lung disease (ILD) diagnoses, defined as non-idiopathic …
Can we define difficult-to-treat systemic sclerosis?
ABSTRACT Introduction Systemic sclerosis (SSc) is a chronic autoimmune rheumatic
disease characterized by microvascular alterations, immunopathology, and widespread …
disease characterized by microvascular alterations, immunopathology, and widespread …
Leukocyte telomere length: the dawn of a new era of personalised medicine in fibrotic interstitial lung diseases?
Extract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrotic lung
disease of unknown cause [1]. Other types of pulmonary fibrosis may exhibit a phenotype of …
disease of unknown cause [1]. Other types of pulmonary fibrosis may exhibit a phenotype of …
Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies
C Campochiaro, N Farina, G De Luca, V Batani… - Arthritis Research & …, 2024 - Springer
Introduction Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous
group diseases, and their treatment is not fully defined yet. According to previous small case …
group diseases, and their treatment is not fully defined yet. According to previous small case …