Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Ferroptosis is an iron-dependent regulated necrosis mediated by lipid peroxidation. Cancer
cells survive under metabolic stress conditions by altering lipid metabolism, which may alter …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Background Immunotherapy represents the future of clinical cancer treatment. The type of
cancer cell death determines the antitumor immune response and thereby contributes to the …

Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD)
characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has …