[HTML][HTML] 4-Hydroxy-nonenal—A bioactive lipid peroxidation product
This review on recent research advances of the lipid peroxidation product 4-hydroxy-
nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues …
nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues …
Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice
Oxidative damage including lipid peroxidation is widely reported in Alzheimer's disease
(AD) with the peroxidation of phospholipids in membranes being the driver of ferroptosis, an …
(AD) with the peroxidation of phospholipids in membranes being the driver of ferroptosis, an …
Protective effect of quercetin in primary neurons against Aβ (1–42): relevance to Alzheimer's disease
Quercetin, a flavonoid found in various foodstuffs, has antioxidant properties and increases
glutathione (GSH) levels and antioxidant enzyme function. Considerable attention has been …
glutathione (GSH) levels and antioxidant enzyme function. Considerable attention has been …
Oxidative Stress and β-Amyloid Protein in Alzheimer's Disease
Z Cai, B Zhao, A Ratka - Neuromolecular medicine, 2011 - Springer
Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …
Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin
SA Rosales‐Corral, D Acuña‐Castroviejo… - Journal of pineal …, 2012 - Wiley Online Library
Alzheimer's disease (AD) is a highly complex neurodegenerative disorder of the aged that
has multiple factors which contribute to its etiology in terms of initiation and progression. This …
has multiple factors which contribute to its etiology in terms of initiation and progression. This …
Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics
Abstract I. Introduction 00 II. Reactive Oxygen and Nitrogen Species 00 III. Biological
Markers of Oxidative/Nitrosative Stress 00 IV. Oxidative/Nitrosative Stress and Protein …
Markers of Oxidative/Nitrosative Stress 00 IV. Oxidative/Nitrosative Stress and Protein …
ER stress and impaired autophagy flux in neuronal degeneration and brain injury
Y Yin, G Sun, E Li, K Kiselyov, D Sun - Ageing research reviews, 2017 - Elsevier
Autophagy is a highly controlled lysosome-mediated function in eukaryotic cells to eliminate
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …
The antioxidants α‐lipoic acid and N‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
SA Farr, HF Poon, D Dogrukol‐Ak… - Journal of …, 2003 - Wiley Online Library
Oxidative stress may play a crucial role in age‐related neurodegenerative disorders. Here,
we examined the ability of two antioxidants, α‐lipoic acid (LA) and N‐acetylcysteine (NAC) …
we examined the ability of two antioxidants, α‐lipoic acid (LA) and N‐acetylcysteine (NAC) …
[HTML][HTML] Mitophagy links oxidative stress conditions and neurodegenerative diseases
U Shefa, NY Jeong, IO Song, HJ Chung… - Neural regeneration …, 2019 - journals.lww.com
Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and
increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress …
increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress …
Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
LE Goldstein, JA Muffat, RA Cherny, RD Moir… - The Lancet, 2003 - thelancet.com
Summary Background Pathological hallmarks of Alzheimer's disease include cerebral β-
amyloid (Aβ) deposition, amyloid accumulation, and neuritic plaque formation. We aimed to …
amyloid (Aβ) deposition, amyloid accumulation, and neuritic plaque formation. We aimed to …