[HTML][HTML] 4-Hydroxy-nonenal—A bioactive lipid peroxidation product

RJ Schaur, W Siems, N Bresgen, PM Eckl - Biomolecules, 2015 - mdpi.com
This review on recent research advances of the lipid peroxidation product 4-hydroxy-
nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues …

Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice

L Chen, NJ Dar, R Na, KD McLane, K Yoo… - Free Radical Biology …, 2022 - Elsevier
Oxidative damage including lipid peroxidation is widely reported in Alzheimer's disease
(AD) with the peroxidation of phospholipids in membranes being the driver of ferroptosis, an …

Protective effect of quercetin in primary neurons against Aβ (1–42): relevance to Alzheimer's disease

MA Ansari, HM Abdul, G Joshi, WO Opii… - The Journal of nutritional …, 2009 - Elsevier
Quercetin, a flavonoid found in various foodstuffs, has antioxidant properties and increases
glutathione (GSH) levels and antioxidant enzyme function. Considerable attention has been …

Oxidative Stress and β-Amyloid Protein in Alzheimer's Disease

Z Cai, B Zhao, A Ratka - Neuromolecular medicine, 2011 - Springer
Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin

SA Rosales‐Corral, D Acuña‐Castroviejo… - Journal of pineal …, 2012 - Wiley Online Library
Alzheimer's disease (AD) is a highly complex neurodegenerative disorder of the aged that
has multiple factors which contribute to its etiology in terms of initiation and progression. This …

Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics

I Dalle‐Donne, A Scaloni, D Giustarini… - Mass spectrometry …, 2005 - Wiley Online Library
Abstract I. Introduction 00 II. Reactive Oxygen and Nitrogen Species 00 III. Biological
Markers of Oxidative/Nitrosative Stress 00 IV. Oxidative/Nitrosative Stress and Protein …

ER stress and impaired autophagy flux in neuronal degeneration and brain injury

Y Yin, G Sun, E Li, K Kiselyov, D Sun - Ageing research reviews, 2017 - Elsevier
Autophagy is a highly controlled lysosome-mediated function in eukaryotic cells to eliminate
damaged or aged long-lived proteins and organelles. It is required for restoring cellular …

The antioxidants α‐lipoic acid and N‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

SA Farr, HF Poon, D Dogrukol‐Ak… - Journal of …, 2003 - Wiley Online Library
Oxidative stress may play a crucial role in age‐related neurodegenerative disorders. Here,
we examined the ability of two antioxidants, α‐lipoic acid (LA) and N‐acetylcysteine (NAC) …

[HTML][HTML] Mitophagy links oxidative stress conditions and neurodegenerative diseases

U Shefa, NY Jeong, IO Song, HJ Chung… - Neural regeneration …, 2019 - journals.lww.com
Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and
increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress …

Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease

LE Goldstein, JA Muffat, RA Cherny, RD Moir… - The Lancet, 2003 - thelancet.com
Summary Background Pathological hallmarks of Alzheimer's disease include cerebral β-
amyloid (Aβ) deposition, amyloid accumulation, and neuritic plaque formation. We aimed to …