Central nervous system cytotoxicity is linked to neurodegenerative disorders. The objective
of the study was to investigate whether monosodium glutamate (MSG) neurotoxicity can be …

Chromosomal DNA dysfunction plays a role in mammalian cell death. Oxidative stress
producing reactive oxygen species (ROS) induces chromatin dysfunction such as single-and …

Reduction and oxidation reactions are essential for biochemical processes. They are part of
metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second …

Protein S-glutathionylation, the reversible binding of glutathione to protein thiols (PSH), is
involved in protein redox regulation, storage of glutathione, and protection of PSH from …

Aging, defined as the gradual alteration in structure and function that occurs over time,
eventually leads to increased probability of nondisease-or nontrauma-related death [1] …

The pervasive action of oxidative stress on neuronal function and plasticity after traumatic
brain injury (TBI) is becoming increasingly recognized. Here, we evaluated the capacity of …

Alzheimer's disease is the most common and lethal neurodegenerative disorder. The major
hallmarks of Alzheimer's disease are extracellular aggregation of amyloid β peptides and …

The predominant molecular symptom of aging is the accumulation of altered gene products.
Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox …

[Frontiers in Bioscience 12, 1107-1123, January 1, 2007] 1107 Mitochondrial dysfunction, free
radical generation and cellular st Page 1 [Frontiers in Bioscience 12, 1107-1123, January 1 …

Microglia plays a critical role in the brain and protects neuronal cells from toxins. However,
over-activation of microglia leads to deleterious effects. Lipopolysaccharide (LPS) has been …