Tim R. Mosmann and Subash Sad he T helper 1 (Thl) and Th2 patterns of cytokine
production were originally described among mouse CD4'T-cell clone@ and later among …

Infection of humans with the nematode worm parasite Anisakis simplex was first described in
the 1960s in association with the consumption of raw or undercooked fish. During the 1990s …

Histomorphology remains a powerful routine evaluating intestinal inflammation in animal
models. Emphasizing the focus of a given animal study, histopathology can overstate …

Summary Interleukin-10 (IL-10) affects the growth and differentiation of many hemopoietic
cells in vitro; in particular, it is a potent suppressor of macrophage and T cell functions. In IL …

Development of the appropriate CD4+ T helper (TH) subset during an immune response is
important for disease resolution. With the use of naive, ovalbumin-specific αβ T cell receptor …

The induction of optimal systemic antitumor immunity involves the priming of both CD4+ and
CD8+ T cells specific for tumor-associated antigens. The role of CD4+ T helper cells (Th) in …

Both metazoan parasites and simple protein allergens induce T helper type 2 (TH2) immune
responses, but the mechanisms by which the innate immune system senses these stimuli …

THE Fos and Jun families of eukaryotic transcription factors heterodimerize to form
complexes capable of binding 5'-TGAGTCA-3'DNA elements. We have determined the X-ray …

Only natural selection can account for the extreme genetic diversity of genes of the major
histocompatibility complex (MHC). Although the structure and function of classic MHC genes …

A fundamental puzzle in immunology is how the immune system decides what types of
immune responses to launch against different stimuli. Although much is known about control …