In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …

Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the
context in which an antigen is perceived, preserving the balance between immunity and …

Personalized cancer vaccines are a promising approach for inducing T cell immunity to
tumor neoantigens. Using a self-assembling nanoparticle vaccine that links neoantigen …

The understanding of the functions of the immune system needs a fundament of solid
anatomical knowledge. The construction and arrangement of the different components of the …

Intravenously administered cyclic dinucleotides and other STING agonists are hampered by
low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of …

The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T
lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has …

While inbred mice have informed most of what we know about the immune system in the
modern era, they have clear limitations with respect to their ability to be informative …

As the world endures the coronavirus disease 2019 (COVID-19) pandemic, the conditions of
35 million vulnerable individuals struggling with substance use disorders (SUDs) worldwide …

The spleen, an important tissue for the immune system, acts as a filter for blood within the
immune system. Accumulating evidence suggests that the spleen affects a number of brain …